Risk Assessment
HIGH
Obesity/Weight
6 years • Mixed Breed
Report ID: EUGENEAGCOEL3004
Risk Assessment
HIGH
Obesity/Weight
What can I help you with?
Primary Insights
Aggressive preventive management is essential throughout his life — strict portion control, food security, and veterinary nutrition support.
| Gene | Function | Result |
|---|---|---|
| POMC | Appetite regulation, satiety | High Risk Variant |
| MC4R | Melanocortin receptor, hunger signaling | Moderate Risk Variant |
| DENND1B | MC4R trafficking, appetite control | No Variant Detected |
| Chr24 Obesity Locus | General obesity predisposition | Moderate Risk Variant |
Critical findings: Max carries multiple genetic variants that significantly increase his risk for obesity and weight gain. This includes major appetite regulation genes that can cause persistent hunger and reduced metabolic efficiency. Aggressive preventive management is essential throughout his life.
We screened Max's DNA for key genes tied to appetite regulation, metabolism, and weight management:
| Gene Tested | Related Risk | Max's Status |
|---|---|---|
| POMC | Appetite regulation, satiety | High-risk variant detected (homozygous) |
| MC4R | Melanocortin receptor, hunger signaling | Risk variant detected (heterozygous) |
| DENND1B | MC4R trafficking, appetite control | ✅No variant detected |
| Chr24 Obesity Locus | General obesity predisposition | Risk variant detected (heterozygous) |
| Category | Result |
|---|---|
| Appetite Regulation Genes | Major variants affecting hunger and satiety. |
| Metabolic Efficiency | Reduced metabolic rate expected. |
| Inheritance Pattern | Homozygous for major gene (POMC), selective additional carriers (MC4R, Chr24). |
| Cumulative Risk | 2.5x base obesity risk from POMC + MC4R and Chr24 modifiers. |
Max carries two copies of the POMC deletion, which causes constant hunger and food-seeking behaviors. Dogs with this condition often act as if they're starving even after meals.
The POMC deletion typically reduces metabolic rate by 25%, meaning Max burns fewer calories at rest compared to normal dogs.
The POMC and MC4R variants work together in the same biological pathway, while the Chr24 locus represents an additional independent risk factor affecting energy balance.
Critical Considerations for Max's Care:
These findings are based on peer-reviewed veterinary research:
Max's genetic profile: Represents one of the highest genetic risk combinations for canine obesity, requiring maximum intervention.
Report generated based on genetic analysis of sample LUFA0009_swab collected on February 14, 2025. Questions? Contact our genetic counselors at [CONTACT INFO].
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Based on genetic predispositions, not a diagnosis.